abstract：:In a preterm infant, small-for-gestational age, neutropenia persisted from the birth, and periomphalitis symptoms appeared at 23 days of age. Upon administration of granulocyte colony-stimulating factor, the neutrophil count increased, and periomphalitis was recovered. At the same time, the umbilical cord separated at...

journal_title：Clinical laboratory

authors： Sameshima T,Iwatani S,Fukushima S,Taniguchi-Ikeda M,Hashimoto M,Yurugi K,Iijima K,Morioka I

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The multidrug resistance 1 gene (ABCB1) encodes P-glycoprotein (PGP), mainly expressed in the liver and engaged in metabolism of drugs including the immunosuppressant tacrolimus (TAC). ABCB1 single nucleotide polymorphisms (SNP) may significantly alter pharmacokinetics and influence TAC concentrations of kid...

journal_title：Clinical laboratory

authors： Riegersperger M,Plischke M,Steinhauser C,Jallitsch-Halper A,Sengoelge G,Winkelmayer WC,Sunder-Plassmann G,Födinger M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:To investigate the comparison of efficacy evaluation value for cell-free DNA (cfDNA) and CEA in advanced colorectal cancer. METHODS:A total of 40 patients with advanced colorectal cancer were enrolled in this study. By PCR Real-time, changes of plasma ALU247and ALU115 level as well as the cfDNA integrity (A...

journal_title：Clinical laboratory

authors： Yu D,An G,Xu L

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is a major health problem worldwide particularly in Egypt. The humoral immune response has an important function in the control of HCV infection. The aim of this study was to investigate the role of neutralizing antibodies in Hepatitis C Virus (HCV) clearance in infected individuals. ...

journal_title：Clinical laboratory

authors： Tabll AA,Salem EA,El-Abd YS,El-Shenawy RM,Saad A,Abdallah SO,Dawood RM,El-Awady MK

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Automated blood culture systems are routinely used in microbiology laboratories to isolate bacteria and fungi causing bloodstream infections. A novel automated blood culture system, DL-Bt112TM (DL) was compared with the BACTEC 9050TM (BCT) and BacT/Alert 3DTM (B3D) systems for time-to-detection (TTD) using 1...

journal_title：Clinical laboratory

authors： Demiray T,Koroglu M,Altindis M

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Obtaining DNA samples through saliva samples is becoming more common, and more companies are responding to this demand with saliva collection/DNA extraction kits. METHODS:The University of Pittsburgh's School of Dental Medicine maintains a DNA bank, which our lab helps direct. While we have always used Orag...

journal_title：Clinical laboratory

authors： Deeley K,Noel J,Vieira AR

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to compare the diagnostic utility of HE4 with NSE, ProGRP, CYFRA 21-1, CEA, and CA 125 and evaluate their prognostic value in patients with small-cell lung cancer (SCLC). METHODS:HE4, ProGRP, NSE, CYFRA 21-1, CEA, and CA 125 assays were performed in 63 patients with smallcel...

journal_title：Clinical laboratory

authors： Wojcik E,Tarapacz J,Rychlik U,Stasik Z,Sas-Korczynska B,Skotnicki P,Kulpa JK

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:We aimed to investigate the potentially pathogenic bacteria of upper respiratory tract infections (URTIs) and their susceptibilities to different antibiotics. METHODS:Two-hundred adenoid and tonsil specimens from 100 patients who had undergone adenotonsillectomy were obtained and analyzed bacteriologically....

journal_title：Clinical laboratory

authors： Nakipoglu Y,Gunel G,Kanliada D,Aydemir L,Gurler N,Gurler B

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:B-cell activating factor (BAFF) belongs to the TNF superfamily of proteins, which influences the life span of normal and malignant cells. It has been demonstrated that there is an overexpression of BAFF in peripheral blood neutrophils and mononuclear cells in patients with oral squamous cell carcinoma (OSCC)...

journal_title：Clinical laboratory

authors： Jab O Ska E,S Odczyk BE,Wawrusiewicz-Kurylonek N,Dziemia Czyk-Pakie A D,Garley M,Ratajczak-Wrona W,Borys J,Kr Towski A

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:To build and evaluate intrinsic coagulation factor assays which can eliminate the effect of lupus anticoagulants (LAC). METHODS:Commercial silica clotting time confirmatory (SCT-C) reagent containing sufficient synthetic phospholipid and routine activated partial thromboplastin time (APTT) reagent were each...

journal_title：Clinical laboratory

authors： Tang N,Yin S

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Testing for hemoglobin A1C (HbA1C) is useful for following up on glycemic control in diabetic patients as well as in pregnant women. METHODS:A pregnant Chinese woman appeared for regular pregnancy check-ups. While monitoring blood glucose, an HbA1c test was initially performed in the pregnant Chinese woman ...

journal_title：Clinical laboratory

authors： Zhong L,Yan M,Liu M,Xie Y,Xu L,Huang L

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) evolution is thought to proceed by mutations within the six major genotypes. Studies of HCV recombinant genotypes in different parts of the world have recently been initiated. Only a few cases of recombination have been identified worldwide, predominantly in Eastern Europe and Asia. I...

journal_title：Clinical laboratory

authors： Zakalashvili M,Weizenegger M,Bartel J,Markowski M,Zarqua J,Kavsadze S,Kvatadze K,Basheleishvili G,Phirtskhalaishvili T,Dzagania T,Zangurashvili L,Kankia N,Jashiashvili N,Lomidze M,Telia T,Kerashvili V,Zhamutashvili M,Ab

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the plasmatic levels matrix metalloproteinases (MMPs): MMP-2, MMP-3, MMP-9, and their inhibitors (TIMPs): TIMP-1 and TIMP-2 in hypertensive patients and healthy subjects. METHODS:The study involved 60 hypertensive patients and 61 adult healthy controls. Pro-MMP-9 and p...

journal_title：Clinical laboratory

authors： Zayani Y,Allal-Elasmi M,Zidi W,Guizani I,Jacob MP,Feki M,Kaabachi N

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Human papillomavirus is a major etiologic agent for some human common cancers. Cervical precancer and cancer is the most prevalent dysplasia by HPV genotypes. Various rapid and sensitive methods have been developed into readily HPV genotyping. METHODS:In the present study, we compared the performance of Rea...

journal_title：Clinical laboratory

authors： Sohrabi A,Rahnamaye-Farzami M,Mirab-Samiee S,Mahdavi S,Babaei M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Suppression of Aurora kinase A (Aurora-A, AURKA) by Aurora-A siRNA has been proposed for lung tumor treatment. However, protocols using single administration have shown little benefit in some types of lung tumor. Given that transfection efficiency of Aurora-A siRNA is low due to tightly packed cells in the t...

journal_title：Clinical laboratory

authors： Wang Z,Sun W,Cao J,Cui H,Ma Z

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) is one of the most frequently occurring malignancies with poor prognosis because of its huge heterogeneity and limited available therapeutic options. The nucleolar 58-kDa microspherule protein (MSP58) is involved in a variety of cellular processes. Though MSP58 was identified as a candida...

journal_title：Clinical laboratory

authors： Cui J,Xi H,Cai A,Ma L,Bian S,Zhang K,Wei B,Chen L

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Persistent high-risk HPV infection is a major cause of cervical cancer and E6/E7 genes and the Li gene in the HPV genome are key targets to detect high-risk HPV. This study aims to explore the relationship between cervical lesions and E6/7 by establishing a polymerase chain reaction (PCR) to detect multiplex...

journal_title：Clinical laboratory

authors： Zou R,Xie W,Wang H,Wang J,Xiao L,Ji S,Chen X,Zhang L,Xue X,Chen J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The economic effects of Point-of-Care (POC) coagulation testing including Multiple Electrode Aggregometry (MEA) with the Multiplate device have not been examined. METHODS:A health economic model with associated clinical endpoints was developed to calculate the effectiveness and estimated costs of coagulatio...

journal_title：Clinical laboratory

authors： Straub N,Bauer E,Agarwal S,Meybohm P,Zacharowski K,Hanke AA,Weber CF

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Adducin is a membrane cytoskeletal protein, consisting of three subunits: α, β, and γ subunits encoded by three different genes (ADD1, ADD2, ADD3). A specific mutation G460T of the α-adducin gene (ADD1) is associated with high renal tubular sodium reabsorption. This mutation is associated with salt sensitivi...

journal_title：Clinical laboratory

authors： Soualmia H,Ben Romdhane A,Midani F,Kallel A,Jemaa R,Feki M,Kaabachi N

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The mutations in the dual oxidase maturation factor 2 (DUOXA2) and dual oxidase 2 (DUOX2) genes have been identified in patients with congenital hypothyroidism (CH). This study reports a set of dizygotic twins with CH due to the mutations in the DUOX2/DUOXA2 system. METHODS:The dizygotic twins, a boy and a ...

journal_title：Clinical laboratory

authors： Yang LX,Ma SG,Qiu YL,Zheng X

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Measuring serum magnesium plays an important role in the diagnosis of diseases. The performance of serum magnesium measurements is most conveniently monitored by external quality assessment (EQA) or proficiency testing (PT) schemes. However, the commutability of EQA samples and calibrators is often unknown, ...

journal_title：Clinical laboratory

authors： Ge M,Zhao H,Yan Y,Zhang T,Zeng J,Wang Y,Meng Q,Zhang C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Aberrant DNA methylation status early in carcinogenesis represents a potential indicator of tumor detection. We would like to establish a DNA methylation biomarker panel for bladder cancer detection in the research. METHODS:Seven candidate genes with known cancer associations were selected for this study. T...

journal_title：Clinical laboratory

authors： Wang K,Tian Y,Xu H

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cause of cancer diagnosed in males and the second in females. Survival is strongly related to stage at diagnosis. There is an urgent need to find a noninvasive biomarker that can be commonly applied for screening diagnosis, early detection of recurrence, and m...

journal_title：Clinical laboratory

authors： Erdemli HK,Kocabas R,Salis O,Sen F,Akyol S,Eskin F,Akyol O,Bedir A,Sahin AF

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Ethics has become increasingly important in the medical field, resulting in the heightened enforcement of institutional review boards (IRBs). Doctors in laboratory medicine have frequently distinguished themselves not only as researchers but also as scientific members on IRBs. METHODS:In line with thoughts ...

journal_title：Clinical laboratory

authors： Shin S,Kim MA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) leading to kidney failure and end stage renal disease (ESRD) is a common health problem associated with wasting syndrome characterized by inadequate nutrient intake and decrease tissue anabolism and/or catabolism. In CKD adipokines, especially leptin and adiponectin (ADPN), accum...

journal_title：Clinical laboratory

authors： Yahya RS,Atwa MA,El-Sayed IH,El-Ghanaam DM,Hussein DT,El-Taweel FA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:MicroRNA-186 (miR-186) plays an important role in the pathogenesis of several cancers. Our study was intended to investigate the expression status and the prognostic implication of miR-186 in acute myeloid leukemia (AML). METHODS:Real-time quantitative PCR was carried out in 112 de novo AML patients and 28 ...

journal_title：Clinical laboratory

authors： Zhang TJ,Wang YX,Yang DQ,Yao DM,Yang L,Zhou JD,Deng ZQ,Wen XM,Guo H,Ma JC,Lin J,Qian J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Aromatase which is encoded by the CYP19 gene is a key enzyme in the conversion of androgen to estrogen and plays an important role in the balance of the gender hormone levels. The gender hormone has a causal role in the development of cardiovascular disease. The goal of this study was to investigate the inte...

journal_title：Clinical laboratory

authors： Fu YZ,Wang B,Ma TY,Huang D,Liu F,Dong LC,Wang T,Meng JY

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Recently, an increasing interest has been extended to the secretory products of fat tissue adipokines and their role in the course of acute pancreatitis (AP). The study aimed to evaluate the levels of adiponectin (ADP), adipocyte fatty acid binding protein (A-FABP), fibroblast growth factor (FGF 21), and sel...

journal_title：Clinical laboratory

authors： Novotny D,Malina P,Krumpholcova P,Tozzi I

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine if the clinical nitrate, Imdur, has a hepato-protective effect in chronic mountain sickness (CMS). METHODS:A total of 60 SD rats were included in the study. Fifty rats were used to model CMS and were randomly divided into the following groups (10 rats per group):...

journal_title：Clinical laboratory

authors： Wanglei,Maimaitiyimin D,Tao Y,Shi W,Upur H,Aikemu A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Studies on transdermal administration have shown that puerarin can permeate rat skin rapidly with long-term drug delivery, but there are no reports demonstrating whether topical use of puerarin can provide a steady plasma concentration to produce therapeutic effects. The aim of the study is to evaluate the p...

journal_title：Clinical laboratory

authors： Wang D,Liu CS,Lv J,Lv YI,Tong WH,Hu JH,Shi LF

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The use of Reference Change Values (RCV) has been advocated as very useful for monitoring individuals. Most of these are performed for monitoring individuals in acute situations and for following up the improvement or deterioration of chronic diseases. In our study, we aimed at evaluating the RCV calculation...

journal_title：Clinical laboratory

authors： Bugdayci G,Oguzman H,Arattan HY,Sasmaz G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The antiproliferative effect of the active form of vitamin D on cancer cells and its ability to induce cell differentiation and suppression of tumor-induced angiogenesis in the last decade has provoked enormous research for the elucidation of its role in the prevention of different types of cancer and in slo...

journal_title：Clinical laboratory

authors： Galunska B,Gerova D,Kosev P,Anakievski D,Hinev A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The aim of this research was to study the effectiveness of perfusion of intact ovine ovaries with different rates of perfusion and time-period elapsed between extraction of these ovaries and the beginning of perfusion. METHODS:Ovaries were perfused through the arteria ovarica (ovarian arteries) with culture...

journal_title：Clinical laboratory

authors： Isachenko V,Isachenko E,Sanchez R,Dattena M,Mallmann P,Rahimi G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:One of the main causes of acute kidney injury (AKI) in patients treated on an intensive care unit (ICU) is sepsis. The identification of new biomarkers indicating the early development and future course of AKI are of utmost medical interest. The C-terminal agrin fragment (CAF) is measurable in blood serum an...

journal_title：Clinical laboratory

authors： Drey M,Behnes M,Kob R,Lepiorz D,Hettwer S,Bollheimer C,Sieber CC,Bertsch T,Hoffmann U

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is one of the most common malignancies worldwide and the incidence is increasing in developed as well as developing countries including Kazakhstan. Glutathione S-transferases (GSTs) are considered to be cancer susceptibility genes as they play a role in the detoxification of carcinoge...

journal_title：Clinical laboratory

authors： Zhunussova G,Zhunusbekova B,Djansugurova L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In this study, we aimed to establish a chronic intermittent hypoxia model in rats and explore the possible role of vaspin in insulin sensitivity. METHODS:Healthy male Wistar rats were randomly divided into two groups: normal control group (NC) and chronic intermittent hypoxia group (CIH). The NC group was r...

journal_title：Clinical laboratory

authors： Zhuang X,Ni Y,Jiang D,Pu Y,Liu X,Chen S,Sun F,Sun A,Pan Z

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Secondary osteoarthritis after ligament or meniscus injury generally causes great burdens to patients. Alpha-melanocyte-stimulating hormone (α-MSH ), a 13 amino acid neuropeptide produced by intracellular cleavage of the proopiomelanocortin (POMC) hormone, has been proven to suppress inflammation and protect...

journal_title：Clinical laboratory

authors： Liu T,Yao Z,He M,Tian C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The phosphoinositide 3 kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) pathway is a complicated intracellular pathway which leads to cell growth and tumor proliferation and plays a significant role in breast cancer. Multiple compounds targeting this pathway are being evaluated in clinical trials. ...

journal_title：Clinical laboratory

authors： Ji Y,Di W,Yang Q,Lu Z,Cai W,Wu J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. In recent years, numerous experimental and clinical studies have demonstrated the efficacy of autologous stem cell transplantation. Electrophysiological measurements are critical to assess the progress and evaluate the prognosis of ...

journal_title：Clinical laboratory

authors： Sun D,Shao X,Zhang X,Han J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Interassay variability is one of the challenging issues of routine clinical laboratory practice. Commercial plasma cortisol immunoassays are also subject to this issue. In this study, we intended to evaluate the interchangeability of cortisol results of three widely used immunoassay systems. METHODS:The cor...

journal_title：Clinical laboratory

authors： Yücel N,Madenci ÖÇ,Bölük A,Köroğlu L,Temel Y,Orçun A

更新日期：2015-01-01 00:00:00